CONSTRUCTII NANOCOMPOZITE INOVATIVE IMPRIMATE 3D OBTINUTE DIN RESURSE MARINE (ALGINAT, SALECAN)
SI ARGILA NATURALA CU APLICATII SPECIFICE IN REGENERAREA OSOASA - 3D_ALSAC

DATE GENERALE

Finantare: Buget de stat
Program: PNCDI III-Program 2: Cresterea competitivitatii economiei romanesti prin cercetare, dezvoltare si inovare, Proiect experimental demonstrativ
Cod proiect: PN-III-P2-2.1-PED-2019-4216
Titlul proiectului: Constructii nanocompozite inovative imprimate 3D obtinute din resurse marine (alginat, salecan) si argila naturala cu aplicatii specifice in regenerarea osoasa (3D_ALSAC)
Contract de finantare: 332/2020
Valoarea totala a contractului: 600000 lei
Valoare de la bugetul de stat: 600000 lei
Durata proiectului: 24 luni
Perioada de derulare a proiectului: 03.08.2020 - 02.08.2022
Contractor: Institutul National de Cercetare Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti
Autoritate contractanta: Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii
Director proiect: Dr. ing. Raluca Ianchis; e-mail: ralumoc@yahoo.com; raluca.ianchis@icechim-pd.ro


PARTENERI

Coordonator:INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU CHIMIE SI PETROCHIMIE-ICECHIM, Splaiul Independentei 202, Bucuresti, 060021, tel: 021.315.32.99, fax: 021.312.34.93
Director proiect: Dr. ing. Raluca Ianchis, tel. 021 316 30 93/int 132, email: ralumoc@yahoo.com; raluca.ianchis@icechim-pd.ro
Partener 1: UNIVERSITATEA POLITEHNICA DIN BUCURESTI, Splaiul Independentei 313, sector 6, 60042, tel: 021 402 3927, fax: 021.402.39.35
Responsabil de proiect: Dr. ing. Horia Iovu, tel. 0745.123.211, Fax: 021.311.17.96, email: iovu@tsocm.pub.ro
Partener 2: GENETIC LAB S.R.L., Bulevardul Ghencea 43B, Bucuresti, sector 6, 012273, tel: 0747.225.341, fax: 021.440.18.78, e-mail: office@geneticlab.ro
Responsabil de proiect: Lorand Savu, fax: 021.440.18.78, email: lorand_savu@yahoo.com


REZUMAT

Scopul proiectului 3D_ALSAC este sa dezvolte si sa testeze modele demonstrative pentru un nou produs si tehnologia asociata acestuia, si anume o formulare de printare eficienta si imbunatatita bazata pe un biomaterial inovativ, urmata de constructia unui implant 3D multifunctional proiectat pentru regenerarea de tesut osos. Pe baza unui fundal solid construit din rezultate teoretice si experimentale obtinute anterior de catre partenerii Consortiului, justificand astfel TRL2, obiectivul acestui proiect este sa tinteasca TRL4, unde un produs inovator printat 3D pe baza de nanocompozit biopolimer-argila va fi dezvoltat, testat si validat. Conceptul proiectului 3D_ALSAC rezoneaza cu viziunea pe termen lung a echipelor de cercetare si in special cea a agentului economic, aceea de dezvoltare a unor matrici extracelulare personalizate pentru regenerarea osoasa utilizand celulele stem ale pacientului. Astfel, proiectul 3D_ALSAC deschide noi posibilitati de colaborare cu mediul economic pentru a implementa solutii eficiente si rentabile. Proiectul 3D_ALSAC va conduce la evolutia domeniilor stiinta materialelor si medicina regenerativa prin repararea unor parti din scheletul corpului uman folosind cerneluri inovatoare pe baza de biomaterial si tehnici de imprimare 3D si obtinerea unor unor implanturi personalizate, servind drept fundament pentru noi terapii folosite pentru regenerarea tesutului osos.


OBIECTIVUL PROIECTULUI

Obiectivul proiectului 3D_ALSAC este sa dezvolte si sa testeze modele demonstrative pentru un nou produs si tehnologia asociata acestuia, si anume o formulare de printare eficienta si imbunatatita bazata pe un biomaterial inovativ, urmata de constructia unui implant 3D multifunctional proiectat pentru regenerarea de tesut osos.


REZULTATE

ESTIMATE

• 1 metoda de sinteza a sistemului ALSA-CGF;
• 1 proces optimizat de obtinere a produsului ALSA-CGF/3D_ALSA-CGF;
• 1 model experimental de laborator pentru produsul ALSA-CGF/3D_ALSA-CGF;
• 1 tehnologie de laborator optimizata pentru produsul ALSA-CGF/3D_ALSA-CGF;
• 1 protocol de lucru pentru validarea modelului experimental de laborator;
• 1 pagina web pentru promovarea proiectului;
• 2 cereri de brevet;
• participare la cel putin 7 evenimente stiintifice nationale/internationale;
• 4 articole trimise pentru publicare;
• contributii la dezvoltarea a 2 teze de doctorat/master/licenta.

1. R.L. Alexa, H. Iovu, I.C. Radu, G. Vlasceanu, C.M. Ninciuleanu, E. Alexandrescu, C. Mihaescu, C. Scomoroscenco, C. Nistor, C. Petcu, R. Ianchis, "Innovative Hydrogel Based Inks with Application in Tissue Engineering", Priorities of Chemistry for a Sustainable Development - PRIOCHEM XVI ed., Bucharest, Romania, 28-30 October (2020).
2. R.L. Alexa, H. Iovu, C. Zaharia, C. Ninciuleanu, B. Trica, E. Alexandrescu, S. Preda, A. Serafim, I.C. Radu, G. Vlasceanu, L. Miclea, R. Ianchis, "Novel Biopolymeric Based Composites Inks for Tissue Engineering Application", 3rd International Conference on Emerging Technologies in Materials Engineering-EmergeMAT, Bucharest, Romania, 29-30 October (2020).

1. R.L. Alexa, H. Iovu, J. Ghitman, A. Serafim, C. Stavarache, M.M. Marin, R. Ianchis, "3D-printed gelatin methacryloyl-based scaffolds with potential application in tissue engineering", Polymers, 2021, 13(5), 727.
2. R.L. Alexa, H. Iovu, B. Trica, C. Zaharia, A. Serafim, E. Alexandrescu, I.C. Radu, G. Vlasceanu, S. Preda, C.M. Ninciuleanu, R. Ianchis, "Assessment of naturally sourced mineral clays for the 3D printing of biopolymer-based nanocomposite inks", Nanomaterials, 2021, 11(3), 703.
3. C.M. Ninciuleanu, R. Ianchis, E. Alexandrescu, C.I. Mihaescu, C. Scomoroscenco, C.L. Nistor, S. Preda, C. Petcu, M. Teodorescu, "The effects of monomer, crosslinking agent, and filler concentrations on the viscoelastic and swelling properties of poly(methacrylic acid) hydrogels: A Comparison", Materials, 2021, 14(91), 2305.
4. R. L. Alexa, H. Iovu, M.C. Nicolae, I.C. Mihaescu, E. Alexandrescu, R.Ianchis, "3D printing of super concentrated alginate clay ink with potential application in regenerative medicine", UPB Scientific Bulletin, Series B: Chemistry and Materials, 2021.
5. R.L Alexa, R. Ianchis, D. Savu, M. Temelie, B. Trica, A. Serafim, G.M. Vlasceanu, E. Alexandrescu, S. Preda, H. Iovu, "3D Printing of Alginate-Natural Clay Hydrogel-Based Nanocomposites", Gels, 2021, 7(4), 211.

1. R.L. Alexa, H. Iovu, G.Vlasceanu, A. Serafim, E. Alexandrescu, S. Preda, R. Ianchis, "3D Printable ink based on alginate and layered silicates", NeXT-Chem III, Bucharest, Romania (2021).
2. C.M. Ninciuleanu, R. Ianchis, E. Alexandrescu, I.C. Mihaescu, S. Preda, C. Scomoroscenco, S. Burlacu, L.C. Nistor, C. Petcu, M. Teodorescu, "Polymetchacrylic Acid Composite Hydrogels with Potential Uses As Devices in Medical and Environmental Protection Fields", Webinar on Nanotechnology-Phronesis LLC, 25-26 January (2021).
3. R.L. Alexa, H. Iovu, G. Vlasceanu, A. Serafim, E. Alexandrescu, S. Preda, R. Ianchis, "Scaffolds obtained by 3D Printing based on alginate-clay hybrid nanocomposites", Bucharest Polymer Conference 2-nd Edition, University POLITEHNICA of Bucharest, Romania, 10-11 June (2021).
4. R. Ianchis, C.M. Ninciuleanu, E. Alexandrescu, I.C. Gifu, R. Gabor, C. Mihaescu, C. Scomoroscenco, S. Nitu, C. Nistor, C. Petcu, H. Iovu, R.L. Alexa, "Investigation of crosslinked hydrogels based on Salecan biopolymer", Bucharest Polymer Conference 2-nd Edition, University POLITEHNICA of Bucharest, Romania, 10-11 June (2021).
5. M.M. Marin, R. Leu, M.G. Albu Kaya, E. Alexandrescu, S. Preda, H. Iovu, R. Ianchis, "Development of New Collagen/Clay Composite Biomaterials", Bucharest Polymer Conference 2-nd Edition, University POLITEHNICA of Bucharest, Romania, 10-11 June (2021).
6. R.L. Alexa, I.C. Gifu, C. Ninciuleanu, E. Alexandrescu, C. Scomoroscenco, C. Mihaescu, S. Burlacu, C.L. Nistor, C. Petcu, H. Iovu, R. Ianchis, "3D printing of novel polysaccharide based biomaterials foreseen for biomedical applications", 4^th International Conference on Emerging Technologies in Materials Engineering-EmergeMAT, Bucharest, Romania, 4-5 November (2021).
7. R.L. Alexa, C. Ninciuleanu, E. Alexandrescu, C. Mihaescu, S. Preda, C.L. Nistor, C. Petcu, H. Iovu, L. Savu, R. Ianchis, "Synthesis of platelet rich plasma enriched inorganic advanced material with application in regenerative medicine", 4^th International Conference on Emerging Technologies in Materials Engineering-EmergeMAT, Bucharest, Romania, 4-5 November (2021).
8. M.M. Marin, I.C. Gifu, C. Ninciuleanu, E. Alexandrescu, C. Scomoroscenco, S. Burlacu,C.L. Nistor, C. Petcu, H. Iovu, R.L. Alexa, R. Ianchis, "Synthesis and characterization of green crosslinked hydrogels", 4^th International Conference on Emerging Technologies in Materials Engineering-EmergeMAT, Bucharest, Romania, 4-5 November (2021).

1. R. Ianchis, R.L. Alexa, M.M. Marin, C.I. Gifu, C.M. Ninciuleanu, E. Alexandrescu, C. Scomoroscenco, S.G. Burlacu, C.I. Mihaescu, C.L. Nistor, C. Petcu, H. Iovu, "Compozitie si procedeu de obtinere a unor hidrogeluri pe baza de salecan si de utilizare a acestora pentru manufacturare aditiv", A 2021-00643/25.10.2021

1. M.M. Marin, R.Ianchis, R.L. Alexa, I.C. Gifu, M.G.A. Kaya, D.I. Savu, R.C. Popescu, E. Alexandrescu, C.M. Ninciuleanu, S. Preda, M. Ignat, R. Constantinescu, H. Iovu, "Development of New Collagen/Clay Composite Biomaterials", Int. J. Mol. Sci., 2022, 23 (10), 401.
2. R.L. Alexa, A. Cucuruz, C.D. Ghitulica, G. Voicu, L.R. Stamat (Balahura), S. Dinescu, G.M. Vlasceanu, C. Stavarache, R. Ianchis, H. Iovu, M. Costache, "3D printable composite biomaterials based on GelMA and hydroxyapatite powders doped with cerium ions for bone tissue regeneration", Int. J. Mol. Sci., 2022, 23(3), 1841.

1. R. Ianchis, I.C. Gifu, E. Alexandrescu, M.M. Marin, S. Burlacu, C. Mihaescu, C.L. Nistor, C. Petcu, "The synthesis of novel polyssacharide based nanocomposite materials. The study of inorganic filler concentration", Virtual Conference on Applications of Chemistry in Nanosciences and Biomaterials Engineering NanoBioMat 2022 – Summer Edition, 22-24 June (2022).
2. R. Ianchis, I.C. Gifu, E. Alexandrescu, M.M. Marin, S. Burlacu, C. Mihaescu, C.L. Nistor, C. Petcu, "The synthesis of novel polyssacharide based nanocomposite materials. Comparative study of Cloisite clay type", Virtual Conference on Applications of Chemistry in Nanosciences and Biomaterials Engineering NanoBioMat 2022 – Summer Edition, 22-24 June (2022).

1. R. Ianchis, M.M. Marin, R.L. Alexa, C.I. Gifu, C.M. Ninciuleanu, E. Alexandrescu, C. Scomoroscenco, S.G. Burlacu, C.I. Mihaescu, C.L. Nistor, C. Petcu, H. Iovu, "Compozitii si procedeu de obtinere a unor hidrogeluri compozite pe baza de polizaharide naturale si aplicarea acestora in procesul de imprimare tridimensionala", A 2022-00127/16.03.2022